Alfredo Perales-Puchalt, MD, PhD

Alfredo Perales-Puchalt, MD, PhD

Position: Vice President, Research & Development

Alfredo Perales-Puchalt joined Geneos as Director of Research & Development bringing his experience in Immuno-Oncology and DNA-based therapeutics in both the scientific and the clinical development space. He led, in collaboration with Geneos, the preclinical development of DNA-encoded neoantigen-targeting vaccines at the Wistar Institute. Prior to joining Geneos, Dr. Perales-Puchalt was leading clinical development of DNA-encoded CD3 bispecific antibodies for oncology, of which he is also co-inventor. His extensive preclinical training, focused on the research of novel immunotherapies, along with his clinical work as physician and director of clinical development in pharmaceutical industry has equipped Dr. Perales-Puchalt to become a translational scientist in the field of tumor immunology and specifically in the development and implementation of immunotherapies for cancer.

Dr. Perales-Puchalt received his MD with honors from the University of Valencia and completed residency in Obstetrics & Gynecology at La Fe University Hospital (Spain). He received his PhD with honors from the University of Valencia, developing at the Wistar Institute a novel adoptive T cell transfer immunotherapy for the treatment of ovarian cancer. Three of the immunotherapies that he has invented have been licensed and are currently in clinical development, including chimeric antigen receptor T cells, bispecific antibodies, and cancer vaccines. Dr. Perales-Puchalt has authored over 42 peer-reviewed manuscripts and has received grants and awards from funding bodies such as the Department of Defense, the Ovarian Cancer Research Fund, and Fundación Alonso Martin Escudero. He also holds a Bachelors Degree in Statistics in Health Sciences, a Masters Degree in Methodology in Research in Health Sciences, and a Masters Degree in Human Reproduction. He also served as Clinical Research Fellow at the PennState Health Milton S. Hershey Medical Center.